Blar i NTNU Open på forfatter "Itkonen, Harri"
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Castration-resistant prostate cancer cells are dependent on the high activity of CDK7
Pallasaho, Satu; Gondane, Aishwarya; Kuivalainen, Anni; Girmay, Samuel; Moestue, Siver Andreas; Loda, Massimo; Itkonen, Harri (Journal article; Peer reviewed, 2022) -
Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells
Barkovskaya, Anna; Seip, Kotryna; Prasmickaite, Lina; Mills, Ian Geoffrey; Moestue, Siver Andreas; Itkonen, Harri (Peer reviewed; Journal article, 2020)In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen ... -
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey (Journal article; Peer reviewed, 2016)Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ... -
O-GlcNAc Transferase Inhibition Differentially Affects Breast Cancer Subtypes
Barkovskaya, Anna; Seip, Kotryna; Hilmarsdòttir, Bylgja; Mælandsmo, Gunhild Mari; Moestue, Siver Andreas; Itkonen, Harri (Journal article; Peer reviewed, 2019)Post-translational modification of intracellular proteins with a single N-acetylglucosamine sugar (O-GlcNAcylation) regulates signaling, proliferation, metabolism and protein stability. In breast cancer, expression of the ... -
Targeted Cancer Therapy: Overcoming Plasticity and Resistance
Barkovskaya, Anna (Doctoral theses at NTNU;2019:283, Doctoral thesis, 2019)